Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.

ABSTRACT: Sirtuin 1 (SIRT1), an NAD⁺-dependent deacylase, has been identified to be associated with renal tubular inflammatory conditions and metabolic disorders, which are risk factors of nephrolithiasis. To further confirm the role of the SIRT1 in kidney stone formation, the expression of SIRT1 was analyzed based on a mouse model and the genetic polymorphisms of SIRT1 gene was compared between patients with kidney stones and controls. The calcium oxalate (CaOx) crystal-induced renal injury model was established to analyzed the expression of SIRT1 in the kidney tissue of both wild-type and ApoE(-/-) mice. And a total of 430 Eastern Chinese subjects (215 patients with nephrolithiasis and 215 age- and gender-matched controls) were recruited for the present study to investigate the associat

SUBMITTER: Hou J 

PROVIDER: S-EPMC6366414 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature