Ontology highlight
ABSTRACT:
SUBMITTER: Ding L
PROVIDER: S-EPMC6366450 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Cell reports 20181201 11
PARP inhibitors have shown promising clinical activities for patients with BRCA mutations and are changing the landscape of ovarian cancer treatment. However, the therapeutic mechanisms of action for PARP inhibition in the interaction of tumors with the tumor microenvironment and the host immune system remain unclear. We find that PARP inhibition by olaparib triggers robust local and systemic antitumor immunity involving both adaptive and innate immune responses through a STING-dependent antitum ...[more]