Anti-Mullerian hormone levels and incidence of early natural menopause in a prospective study.

ABSTRACT: STUDY QUESTION:Are anti-Müllerian hormone (AMH) levels assessed in women aged 32-44 associated with risk of incident early natural menopause? SUMMARY ANSWER:We observed strong, significant associations between lower AMH levels and higher risk of early menopause. WHAT IS KNOWN ALREADY:The ability to predict risk early menopause, defined as menopause before age 45, prior to fertility decline would improve options for family planning and cardiovascular disease prevention. Though AMH is an established marker of menopause timing in older reproductive-aged women, whether AMH is associated with risk of early menopause has not been evaluated. STUDY DESIGN, SIZE, DURATION:We assessed these relations in a nested case-control study within the prospective Nurses' Health Study II cohort. Premenopausal

SUBMITTER: Bertone-Johnson ER 

PROVIDER: S-EPMC6366539 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature