Neuroinflammation in schizophrenia: meta-analysis of <i>in vivo</i> microglial imaging studies.

ABSTRACT:

Background

Converging lines of evidence implicate an important role for the immune system in schizophrenia. Microglia are the resident immune cells of the central nervous system and have many functions including neuroinflammation, axonal guidance and neurotrophic support. We aimed to provide a quantitative review of in vivo PET imaging studies of microglia activation in patients with schizophrenia compared with healthy controls.

Methods

Demographic, clinical and imaging measures were extracted from each study and meta-analysis was conducted using a random-effects model (Hedge's g). The difference in 18-kDa translocator protein (TSPO) binding between patients with schizophrenia and healthy controls, as quantified by either binding potential (BP) or volume of distribution (VT)

SUBMITTER: Marques TR 

PROVIDER: S-EPMC6366560 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature