Leptin trajectories from birth to mid-childhood and cardio-metabolic health in early adolescence.

ABSTRACT:

Objectives

Leptin is a hormone produced by adipose tissue that promotes satiety, and some evidence suggests that greater early life leptin exposure prevents excessive adiposity gain in later life. However, few studies have analyzed dynamic changes in leptin throughout childhood in relation to later cardio-metabolic health. Our study aims to identify distinct leptin trajectories in childhood, and to examine their associations with cardio-metabolic outcomes in adolescence.

Methods

Among children in the Project Viva cohort born 1999-2002 in Massachusetts, we used latent class growth models to identify leptin trajectories independent of maternal BMI, child sex, race/ethnicity, size at birth and current age and size among 1360 children with leptin measured at least once at birth,

SUBMITTER: Li LJ 

PROVIDER: S-EPMC6366620 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature