Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics.

ABSTRACT: The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa.

SUBMITTER: Sadlowski C 

PROVIDER: S-EPMC6366622 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature