Community-level chlamydial serology for assessing trachoma elimination in trachoma-endemic Niger.

ABSTRACT:

Background

Program decision-making for trachoma elimination currently relies on conjunctival clinical signs. Antibody tests may provide additional information on the epidemiology of trachoma, particularly in regions where it is disappearing or elimination targets have been met.

Methods

A cluster-randomized trial of mass azithromycin distribution strategies for trachoma elimination was conducted over three years in a mesoendemic region of Niger. Dried blood spots were collected from a random sample of children aged 1-5 years in each of 24 study communities at 36 months after initiation of the intervention. A multiplex bead assay was used to test for antibodies to two Chlamydia trachomatis antigens, Pgp3 and CT694. We compared seropositivity to either antigen to clinical signs

SUBMITTER: Kim JS 

PROVIDER: S-EPMC6366708 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature