TIM family gene polymorphism and susceptibility to rheumatoid arthritis: Systematic review and meta-analysis.

ABSTRACT:

Background

TIM-family proteins are expressed on different immune cells such as dendritic cells, macrophages, type 1 and 2 T helper (Th) cells. Therefore, they have the ability to contribute to the various intracellular signals and immune responses, importantly the regulation of Th1 and Th17 cell differentiation, which plays a remarked role in fight against inflammatory and autoimmune diseases. Association of TIM family gene polymorphisms with rheumatoid arthritis (RA) has been frequently investigated. The findings however are not entirely consistent. Therefore, we carried out the present meta-analysis to examine the association between RA and the following TIM family gene polymorphisms: rs41297579, rs1036199, rs10515746, and rs7700944.

Methods

A systematic search of Scopus,

SUBMITTER: Razi B 

PROVIDER: S-EPMC6366744 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature