AHRR (cg05575921) methylation extent of leukocyte DNA and lung cancer survival.

ABSTRACT:

Background

Prior studies have shown that AHRR (cg05575921) hypomethylation may be a marker of smoking, lung cancer risk and potentially lung cancer survival (in some lung cancer subtypes). It is unknown if AHRR (cg05575921) hypomethylation is associated with reduced survival among lung cancer patients.

Methods

In bisulfite treated leukocyte DNA from 465 lung cancer patients from the Copenhagen prospective lung cancer study, we measured AHRR (cg05575921) methylation. 380 died during max follow-up of 4.4 years. Cox proportional hazard models were used to analyze survival as a function of AHRR (cg05575921) methylation.

Results

We observed the expected inverse correlation between cumulative smoking and AHRR methylation, as methylation (%) decreased (Coefficient -0.03; 95%

SUBMITTER: Kemp Jacobsen K 

PROVIDER: S-EPMC6366765 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature