The Genetic Basis of Mutation Rate Variation in Yeast.

ABSTRACT: Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis of these differences. Here, we leveraged the power of the yeast Saccharomyces cerevisiae as a model system to uncover natural genetic variants that underlie variation in mutation rate. We developed a high-throughput fluctuation assay and used it to quantify mutation rates in seven natural yeast isolates and in 1040 segregant progeny from a cross between BY, a laboratory strain, and RM, a wine strain. We observed that mutation rate varies among yeast strains and is heritable (H ² = 0.49). We performed linkage mapping

SUBMITTER: Gou L 

PROVIDER: S-EPMC6366923 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature