Expression and gene regulation network of RBM8A in hepatocellular carcinoma based on data mining.

ABSTRACT: RNA binding motif protein 8A (RBM8A) is an RNA binding protein in a core component of the exon junction complex. Abnormal RBM8A expression is associated with carcinogenesis. We used sequencing data from the Cancer Genome Atlas database and Gene Expression Omnibus, analyzed RBM8A expression and gene regulation networks in hepatocellular carcinoma (HCC). Expression was analyzed using Oncomine^TM and Gene Expression Profiling Interactive Analysis tools, while RBM8A alterations and related functional networks were identified using cBioPortal. LinkedOmics was used to identify differential gene expression with RBM8A and to analyze Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. Gene enrichment analysis examined target networks of kinases,

SUBMITTER: Lin Y 

PROVIDER: S-EPMC6366983 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature