Association between antidiabetic agents use and leukocyte telomere shortening rates in patients with type 2 diabetes.

ABSTRACT: Telomere length and telomere shortening rate (TSR) are accepted indicators of aging in cross-sectional population studies. This study aimed to investigate the potential influence of common antidiabetic agents on telomere length and TSR in patients with type 2 diabetes mellitus (T2DM). Leukocyte telomere length was measured through terminal restriction fragment analysis, and TSR was calculated in 388 T2DM patients. Depending on whether or not they received antidiabetic medication, patients were first divided into a treatment group and a nontreatment group. Treated patients were further subdivided into an acarbose-free group (patients taking antidiabetic agents without acarbose) and an acarbose group (patients using acarbose for more than 3 months). Results showed that untreated patients had

SUBMITTER: Liu J 

PROVIDER: S-EPMC6366988 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature