Mild Cognitive Impairment that Does Not Progress to Dementia: A Population-Based Study.

ABSTRACT:

Background/objective

In population studies, most individuals with mild cognitive impairment (MCI) do not progress to dementia in the near term, but rather remain stable MCI or revert to normal cognition. Here, we characterized MCI subgroups with different outcomes over 5 years.

Setting/participants

A population-based cohort (N=1603).

Measurements

Clinical Dementia Rating (CDR); self-reported medical conditions, subjective cognitive concerns, self-rated health, depressive symptoms, blood pressure, medications, blood pressure, APOE genotype, cognitive domain composite scores.

Design

We compared 3 MCI subgroups who progressed to dementia (n=86), stabilized at MCI (n=384), or reverted to normal (n=252), to those who remained consistently normal (n=881), defining MC

SUBMITTER: Ganguli M 

PROVIDER: S-EPMC6367026 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature