MRI-guided transurethral insonation of silica-shell phase-shift emulsions in the prostate with an advanced navigation platform.

ABSTRACT:

Purpose

In this study, the efficacy of transurethral prostate ablation in the presence of silica-shell ultrasound-triggered phase-shift emulsions (sUPEs) doped with MR contrast was evaluated. The influence of sUPEs on MR imaging assessment of the ablation zone was also investigated.

Methods

sUPEs were doped with a magnetic resonance (MR) contrast agent, Gd₂ O₃ , to assess ultrasound transition. Injections of saline (sham), saline and sUPEs alone, and saline and sUPEs with Optison microbubbles were performed under guidance of a prototype interventional MRI navigation platform in a healthy canine prostate. Treatment arms were evaluated for differences in lesion size, T₁  contrast, and temperature. In addition, non-perfused areas (NPAs) on dynam

SUBMITTER: Anthony GJ 

PROVIDER: S-EPMC6367027 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature