Structure of the post-translational protein translocation machinery of the ER membrane.

ABSTRACT: Many proteins must translocate through the protein-conducting Sec61 channel in the eukaryotic endoplasmic reticulum membrane or the SecY channel in the prokaryotic plasma membrane^1,2. Proteins with highly hydrophobic signal sequences are first recognized by the signal recognition particle (SRP)^3,4 and then moved co-translationally through the Sec61 or SecY channel by the associated translating ribosome. Substrates with less hydrophobic signal sequences bypass the SRP and are moved through the channel post-translationally^5,6. In eukaryotic cells, post-translational translocation is mediated by the association of the Sec61 channel with another membrane protein complex, the Sec62-Sec63 complex^7-9, and substrates are moved through the channel by the

SUBMITTER: Wu X 

PROVIDER: S-EPMC6367035 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature