Local variations in material and structural properties characterize murine thoracic aortic aneurysm mechanics.

ABSTRACT: We recently developed an approach to characterize local nonlinear, anisotropic mechanical properties of murine arteries by combining biaxial extension-distension testing, panoramic digital image correlation, and an inverse method based on the principle of virtual power. This experimental-computational approach was illustrated for the normal murine abdominal aorta assuming uniform wall thickness. Here, however, we extend our prior approach by adding an optical coherence tomography (OCT) imaging system that permits local reconstructions of wall thickness. This multimodality approach is then used to characterize spatial variations of material and structural properties in ascending thoracic aortic aneurysms (aTAA) from two genetically modified mouse models (fibrillin-1 and fibulin-4 deficient)

SUBMITTER: Bersi MR 

PROVIDER: S-EPMC6367054 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature