Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort.

ABSTRACT: Renal transplant recipients have an increased risk of non-melanoma skin cancer (NMSC) compared to in the general population. Here, we show polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of NMSC in a general, nontransplant setting, can predict risk of, and time to posttransplant skin cancer. Genetic variants, reaching predefined P-value thresholds were chosen from published squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) nontransplant GWAS. Using these GWAS, BCC and SCC PRS were calculated for each sample across three European ancestry renal transplant cohorts (n = 889) and tested as predictors of case:control status and time to NMSC posttransplant. BCC PRS calculated at P-value threshold 1 × 10^-5 was the most significant predictor

SUBMITTER: Stapleton CP 

PROVIDER: S-EPMC6367067 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature