Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease.

ABSTRACT: Adult-onset neurodegenerative diseases are among the most difficult human health conditions to model for drug development. Most genetic or toxin-induced cell and animal models cannot faithfully recapitulate pathology in disease-relevant cells, making it excessively challenging to explore the potential mechanisms underlying sporadic disease. Patient-derived induced pluripotent stem cells (iPSCs) can be differentiated into disease-relevant neurons, providing an unparalleled platform for in vitro modelling and development of therapeutic strategies. Here, we review recent progress in generating Alzheimer's, Parkinson's and Huntington's disease models from patient-derived iPSCs. We also describe novel discoveries of pathological mechanisms and drug evaluations that have used these patient iPSC-

SUBMITTER: Wu YY 

PROVIDER: S-EPMC6367134 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature