Large-scale gene analysis of rabbit atherosclerosis to discover new biomarkers for coronary artery disease.

ABSTRACT: Atherosclerosis is the pathological basis of coronary artery disease (CAD) and causes high mortality. Thus, early detection is thought to be crucial in reducing the risk of CAD. Uncovering the mechanisms of the progression and regression of atherosclerosis will provide insights into discovering novel biomarkers to identify subjects at risk for CAD and improve prevention. We established atherosclerosis progression and regression in a rabbit model. Then, we extracted mRNA of the abdominal aorta from control, model and recovery groups to perform gene chip analysis. Candidate biomarkers were screened by large-scale gene analysis and validated in patients with CAD or with CAD recovery by ELISA. The differentially expressed genes in the progression and regression of atherosclerosis were mainly e

SUBMITTER: Yu X 

PROVIDER: S-EPMC6367139 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature