Immune Cell Composition in Human Non-small Cell Lung Cancer.

ABSTRACT: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the world. Immunological analysis of the tumor microenvironment (immunoscore) shows great promise for improved prognosis and prediction of response to immunotherapy. However, the exact immune cell composition in NSCLC remains unclear. Here, we used flow cytometry to characterize the immune infiltrate in NSCLC tumors, non-cancerous lung tissue, regional lymph node, and blood. The cellular identity of >95% of all CD45⁺ immune cells was determined. Thirteen distinct immune cell types were identified in NSCLC tumors. T cells dominated the lung cancer landscape (on average 47% of all CD45⁺ immune cells). CD4⁺ T cells were the most abundant T cell population (26%), closely followed

SUBMITTER: Stankovic B 

PROVIDER: S-EPMC6367276 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature