Ontology highlight
ABSTRACT:
SUBMITTER: Park MK
PROVIDER: S-EPMC6367354 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nature communications 20190207 1
PTEN is a lipid phosphatase that antagonizes the PI3K/AKT pathway and is recognized as a major dose-dependent tumor suppressor. The cellular mechanisms that control PTEN levels therefore offer potential routes to therapy, but these are as yet poorly defined. Here we demonstrate that PTEN plays an unexpected role in regulating its own stability through the transcriptional upregulation of the deubiquitinase USP11 by the PI3K/FOXO pathway, and further show that this feedforward mechanism is implica ...[more]