Voluntary running rescues the defective hippocampal neurogenesis and behaviour observed in lipocalin 2-null mice.

ABSTRACT: The continuous generation of new neurons in the adult mammalian hippocampus is a form of neural plasticity that modulates learning and memory functions, and also emotion (anxiety and depression). Among the factors known to modulate adult hippocampal neurogenesis and brain function, lipocalin-2 (LCN2) was recently described as a key regulator of neural stem cells (NSCs) proliferation and commitment, with impact on several dimensions of behaviour. Herein, we evaluated whether voluntary running, a well-known regulator of cell genesis, rescue the deficient adult hippocampal neurogenesis observed in mice lacking LCN2. We observed that running, by counteracting oxidative stress in NSCs, reverses LCN2-null mice defective hippocampal neurogenesis, as it promotes NSCs cell cycle progression and mat

SUBMITTER: Ferreira AC 

PROVIDER: S-EPMC6367505 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature