Platelet Reactivity And Circulating Platelet-Derived Microvesicles Are Differently Affected By P2Y₁₂ Receptor Antagonists.

ABSTRACT: Background: Platelet-derived microvesicles (PMVs), shed from platelet surface membranes, constitute the majority of circulating microvesicles and have been implicated in procoagulant, pro-inflammatory and pro-atherosclerotic effects. Our aim was to compare plasma PMVs numbers in relation to platelet reactivity during dual antiplatelet therapy (DAPT) with various P2Y₁₂ adenosine diphosphate (ADP) receptor antagonists. Methods: In pre-discharge men treated with DAPT for an acute coronary syndrome, plasma PMVs were quantified by flow cytometry on the basis of CD62P (P-selectin) and CD42 (glycoprotein Ib) positivity, putative indices of PMVs release from activated and all platelets, respectively. ADP-induced platelet aggregation was measured by multiple-electrode aggre

SUBMITTER: Chyrchel B 

PROVIDER: S-EPMC6367525 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature