Plateletpheresis-associated lymphopenia in frequent platelet donors.

ABSTRACT: More than 1 million apheresis platelet collections are performed annually in the United States. After 2 healthy plateletpheresis donors were incidentally found to have low CD4⁺ T-lymphocyte counts, we investigated whether plateletpheresis causes lymphopenia. We conducted a cross-sectional single-center study of platelet donors undergoing plateletpheresis with the Trima Accel, which removes leukocytes continuously with its leukoreduction system chamber. We recruited 3 groups of platelet donors based on the total number of plateletpheresis sessions in the prior 365 days: 1 or 2, 3 to 19, or 20 to 24. CD4⁺ T-lymphocyte counts were <200 cells per microliter in 0/20, 2/20, and 6/20 donors, respectively (P = .019), and CD8⁺ T-lymphocyte counts were low in

SUBMITTER: Gansner JM 

PROVIDER: S-EPMC6367645 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature