A Modular Health-Related Quality of Life Instrument for Electronic Assessment and Treatment Monitoring: Web-Based Development and Psychometric Validation of Core Thrive Items.

ABSTRACT: BACKGROUND:Patient-reported outcome (PRO) measures describe natural history, manage disease, and measure the effects of interventions in trials. Patients themselves increasingly use Web-based PRO tools to track their progress, share their data, and even self-experiment. However, existing PROs have limitations such as being: designed for paper (not screens), long and burdensome, negatively framed, under onerous licensing restrictions, either too generic or too specific. OBJECTIVE:This study aimed to develop and validate the core items of a modular, patient-centric, PRO system (Thrive) that could measure health status across a range of chronic conditions with minimal burden. METHODS:Thrive was developed in 4 phases, largely consistent with Food and Drug Administration guidance regarding PRO

SUBMITTER: Wicks P 

PROVIDER: S-EPMC6367664 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature