Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort.

ABSTRACT:

Aim

Previous studies suggest telomere shortening represses PGC1A and PGC1B expression leading to mitochondrial dysfunction. Methylation of CpG sites within these genes may interact with these factors to affect cancer risk.

Materials & methods

Among 385 men, we identified 84 incidents of cancers (predominantly prostate and nonmelanoma skin). We examined associations between leukocyte DNA methylation of 41 CpGs from PGC1A and PGC1B with telomere length, mitochondrial 8-OHdG lesions, mitochondrial abundance and cancer incidence.

Results

Methylation of five and eight CpG sites were significantly associated with telomere length and mitochondrial abundance at p < 0.05. Two CpG sites were independently associated with cancer risk: cg27514608 (PGC1A, TSS1500; HR: 1.55, 95% CI

SUBMITTER: Kresovich JK 

PROVIDER: S-EPMC6367713 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature