Risk prediction for breast Cancer in Han Chinese women based on a cause-specific Hazard model.

ABSTRACT:

Background

Considering the lack of efficient breast cancer prediction models suitable for general population screening in China. We aimed to develop a risk prediction model to identify high-risk populations, to help with primary prevention of breast cancer among Han Chinese women.

Methods

A cause-specific competing risk model was used to develop the Han Chinese Breast Cancer Prediction model. Data from the Shandong Case-Control Study (328 cases and 656 controls) and Taixing Prospective Cohort Study (13,176 participants) were used to develop and validate the model. The expected/observed (E/O) ratio and C-statistic were calculated to evaluate calibration and discriminative accuracy of the model, respectively.

Results

Compared with the reference level, the relative risks

SUBMITTER: Wang L 

PROVIDER: S-EPMC6367757 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature