Association of four imprinting disorders and ART.

ABSTRACT:

Background

Human-assisted reproductive technologies (ART) are a widely accepted treatment for infertile couples. At the same time, many studies have suggested the correlation between ART and increased incidences of normally rare imprinting disorders such as Beckwith-Wiedemann syndrome (BWS), Angelman syndrome (AS), Prader-Willi syndrome (PWS), and Silver-Russell syndrome (SRS). Major methylation dynamics take place during cell development and the preimplantation stages of embryonic development. ART may prevent the proper erasure, establishment, and maintenance of DNA methylation. However, the causes and ART risk factors for these disorders are not well understood.

Results

A nationwide epidemiological study in Japan in 2015 in which 2777 pediatrics departments were contacted

SUBMITTER: Hattori H 

PROVIDER: S-EPMC6367766 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature