Different role of circulating myeloid-derived suppressor cells in patients with multiple myeloma undergoing autologous stem cell transplantation.

ABSTRACT:

Background

The aim of this study is to evaluate the prognostic impact of myeloid-derived suppressor cells (MDSCs) in multiple myeloma (MM) in the context of autologous stem cell transplantation (ASCT).

Methods

Peripheral blood samples were collected for measuring monocytic (M-) MDSCs (CD14^posHLA-DR^low/neg) and early-stage (E-) MDSCs (Lin^negHLA-DR^negCD33^posCD11b^pos) before and after ASCT. Clinical outcomes following ASCT differed according to the frequency of each MDSC phenotype.

Results

In the pre-ASCT analyses, lower M-MDSCs (

SUBMITTER: Lee SE 

PROVIDER: S-EPMC6367772 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature