Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta.

ABSTRACT:

Background

It is well established that obesity is associated with dysregulation of the ratio between the two major adipokines leptin and adiponectin. Furthermore, it was recently reported that maternal obesity has a significant impact on placental development. Leptin and adiponectin are present at the fetal-maternal interface and are involved in the development of a functional placenta. However, less is known about leptin and adiponectin's involvement in the placental alterations described in obese women. Hence, the objective of the present study was to characterize the placental expression and DNA methylation of these two adipokine systems (ligands and receptors) in obese women.

Results

Biopsies were collected from the fetal and maternal sides of third-trimester placenta in

SUBMITTER: Nogues P 

PROVIDER: S-EPMC6367801 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature