Evolution of the Mutational Process under Relaxed Selection in Caenorhabditis elegans.

ABSTRACT: The mutational process varies at many levels, from within genomes to among taxa. Many mechanisms have been linked to variation in mutation, but understanding of the evolution of the mutational process is rudimentary. Physiological condition is often implicated as a source of variation in microbial mutation rate and may contribute to mutation rate variation in multicellular organisms.Deleterious mutations are an ubiquitous source of variation in condition. We test the hypothesis that the mutational process depends on the underlying mutation load in two groups of Caenorhabditis elegans mutation accumulation (MA) lines that differ in their starting mutation loads. "First-order MA" (O1MA) lines maintained under minimal selection for ∼250 generations were divided into high-fitness and low-fitne

SUBMITTER: Saxena AS 

PROVIDER: S-EPMC6367967 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature