Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh.

ABSTRACT:

Background

Arsenic exposure through drinking water persists in many regions. Inorganic As (InAs) is methylated to monomethyl-arsenical species (MMAs) and dimethyl-arsenical species (DMAs), facilitating urinary excretion. Arsenic methylation is dependent on one-carbon metabolism, which is influenced by nutritional factors such as folate and creatine.

Objective

This study investigated the effects of folic acid (FA) and/or creatine supplementation on the proportion of As metabolites in urine.

Design

In a 24-wk randomized, double-blinded, placebo-controlled trial, 622 participants were assigned to receive FA (400 or 800 μg per day), 3 g creatine per day, 400 μg FA + 3 g creatine per day, or placebo. The majority of participants were folate sufficient; all received As-remo

SUBMITTER: Bozack AK 

PROVIDER: S-EPMC6367980 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature