Sphk2^-/- mice are protected from obesity and insulin resistance.

ABSTRACT: Sphingosine kinases phosphorylate sphingosine to sphingosine 1‑phosphate (S1P), which functions as a signaling molecule. We have previously shown that sphingosine kinase 2 (Sphk2) is important for insulin secretion. To obtain a better understanding of the role of Sphk2 in glucose and lipid metabolism, we have characterized 20- and 52-week old Sphk2^-/- mice using glucose and insulin tolerance tests and by analyzing metabolic gene expression in adipose tissue. A detailed metabolic characterization of these mice revealed that aging Sphk2^-/- mice are protected from metabolic decline and obesity compared to WT mice. Specifically, we found that 52-week old male Sphk2^-/- mice had decreased weight and fat mass, and increased glucose tolerance and insulin sensitivit

SUBMITTER: Ravichandran S 

PROVIDER: S-EPMC6368224 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature