Short-term effects of single-dose chloral hydrate on neonatal auditory perception: An auditory event-related potential study.

ABSTRACT:

Objective

To study the short-term effects of a single-dose chloral hydrate on neonatal auditory perception by measuring auditory event-related potentials (aERPs).

Methods

Thirty-nine full-term neonates, aged 2-28 days and weighing 2980-4350 g, were divided into two groups including a chloral hydrate group (CH group, n = 17) and a non-chloral hydrate control group (non-CH group, n = 22). The CH group was given single-dose chloral hydrate (30 mg/kg) orally before aERPs measurement. An auditory oddball paradigm was used to elicit aERPs. P2 and N2 components of the ERP were recorded from electrodes at the Fz and Cz locations, and the areas under their curves (P2 and N2 areas) were calculated for the comparison between two groups.

Results

Significant differences was found

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6368310 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature