Utility of rabies neutralizing antibody detection in cerebrospinal fluid and serum for ante-mortem diagnosis of human rabies.

ABSTRACT:

Background

Early ante-mortem laboratory confirmation of human rabies is essential to aid patient management and institute public health measures. Few studies have highlighted the diagnostic value of antibody detection in CSF/serum in rabies, and its utility is usually undermined owing to the late seroconversion and short survival in infected patients. This study was undertaken to examine the ante-mortem diagnostic utility and prognostic value of antibody detection by rapid fluorescent focus inhibition test (RFFIT) in cerebrospinal fluid (CSF)/serum samples received from clinically suspected human rabies cases from January 2015 to December 2017.

Methodology/principal findings

Samples collected ante-mortem and post-mortem from 130 and 6 patients with clinically suspected rabie

SUBMITTER: Damodar T 

PROVIDER: S-EPMC6368332 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature