Hypertension Is Associated with White Matter Disruption in Apparently Healthy Middle-Aged Individuals.

ABSTRACT:

Background and purpose

Traditional cardiovascular risk factors have been associated with white matter disease. Because hypertension results in vascular stiffness and impaired cerebral perfusion, we hypothesized that it would be the most relevant risk factor for microstructural white matter disruption in apparently healthy middle-aged individuals with a family history of early-onset coronary artery disease.

Materials and methods

This was a cross-sectional analysis of participants in the Genetic Study of Atherosclerosis Risk with DTI. Regional fractional anisotropy of 181 segmented brain regions was measured using Eve WM Atlas. Risk factors were examined using univariate analysis for 48 regions representing deep WM structures. Minimal multivariable linear regression models adj

SUBMITTER: Hannawi Y 

PROVIDER: S-EPMC6368444 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature