The relationships between markers of tubular injury and intrarenal haemodynamic function in adults with and without type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes.

ABSTRACT:

Objective

Our aim was to define the relationships between plasma biomarkers of kidney injury and intrarenal haemodynamic function (glomerular filtration rate [GFR], effective renal plasma flow [ERPF], renal vascular resistance [RVR]) in adults with type 1 diabetes (T1D).

Methods

The study sample comprised patients with longstanding T1D (duration ≥50 years), among whom 44 were diabetic kidney disease (DKD) resistors (eGFR >60 mL/min/1.73 m² and <30 mg/d urine albumin excretion) and 22 had DKD, in addition to 73 control participants. GFR_INULIN and ERPF_PAH were measured, RVR was calculated, and afferent (R_A )/efferent (R_E ) areteriolar resistances were derived from Gomez equations. Plasma neutrophil gelatinase-associated li

SUBMITTER: Bjornstad P 

PROVIDER: S-EPMC6368468 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature