Ontology highlight
ABSTRACT:
SUBMITTER: Tang W
PROVIDER: S-EPMC6368584 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Nature communications 20190208 1
The biological role of miR-500a-5p has not yet been reported in the context of colorectal cancer (CRC). Here, we show that miR-500a-5p expression is decreased in CRC tissues compared with adjacent normal tissues. Low miR-500a-5p expression is associated with malignant progression. Moreover, transfection of CRC cells with miR-500a-5p induces G0/G1 cell cycle arrest and inhibits their growth and migration. Mechanistically, miR-500a-5p directly targets HDAC2 and inhibits HDAC2-mediated proliferatio ...[more]