Neuronal plasticity affects correlation between the size of dendritic spine and its postsynaptic density.

ABSTRACT: Structural plasticity of dendritic spines is thought to underlie memory formation. Size of a dendritic spine is considered proportional to the size of its postsynaptic density (PSD), number of glutamate receptors and synaptic strength. However, whether this correlation is true for all dendritic spine volumes, and remains stable during synaptic plasticity, is largely unknown. In this study, we take advantage of 3D electron microscopy and reconstruct dendritic spines and cores of PSDs from the stratum radiatum of the area CA1 of organotypic hippocampal slices. We observe that approximately 1/3 of dendritic spines, in a range of medium sizes, fail to reach significant correlation between dendritic spine volume and PSD surface area or PSD-core volume. During NMDA receptor-dependent chemical lo

SUBMITTER: Borczyk M 

PROVIDER: S-EPMC6368589 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature