Networks of ribosome flow models for modeling and analyzing intracellular traffic.

ABSTRACT: The ribosome flow model with input and output (RFMIO) is a deterministic dynamical system that has been used to study the flow of ribosomes during mRNA translation. The input of the RFMIO controls its initiation rate and the output represents the ribosome exit rate (and thus the protein production rate) at the 3' end of the mRNA molecule. The RFMIO and its variants encapsulate important properties that are relevant to modeling ribosome flow such as the possible evolution of "traffic jams" and non-homogeneous elongation rates along the mRNA molecule, and can also be used for studying additional intracellular processes such as transcription, transport, and more. Here we consider networks of interconnected RFMIOs as a fundamental tool for modeling, analyzing and re-engineering the complex mec

SUBMITTER: Nanikashvili I 

PROVIDER: S-EPMC6368613 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature