Personalised insulin calculator enables safe and effective correction of hyperglycaemia prior to FDG PET/CT.

ABSTRACT:

Background

Hyperglycaemia can influence ¹⁸F-fluorodeoxyglucose (FDG) uptake due to competition for glucose transport and phosphorylation by hexokinase. Major international nuclear medicine societies recommend blood glucose level (BGL) < 11.1 mmol/L (200 mg/dL) prior to performing FDG positron emission tomography/computed tomography (PET/CT). However, there is no consensus approach and complications of previously proposed insulin guidelines included significant hypoglycaemia, inconvenience and skeletal muscle uptake. This study aims to establish the safety and efficacy of a personalised insulin calculator protocol to estimate the dose of intravenous insulin injection for correction of hyperglycaemia prior to FDG PET/CT.

Results

This is a retrospective audit of all

SUBMITTER: Pattison DA 

PROVIDER: S-EPMC6368634 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature