Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study.

ABSTRACT:

Background

Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers glutamate release. The aim of the current study was to assess the effect of lamotrigine on brain glutamate in depressed bipolar patients and to determine whether baseline glutamate could be used to predict clinical response.

Methods

We studied 21 bipolar patients who received lamotrigine treatment for a current episode of depression. Before starting lamotrigine and after 10-12 weeks treatment, patients underwent proton magnetic resonance spectroscopy (MRS) scanning at 3 Tesla where levels of glutamate (measured as Glx) were determined in anterior cingulate corte

SUBMITTER: Godlewska BR 

PROVIDER: S-EPMC6368663 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature