Hsa_circRNA_0054633 is highly expressed in gestational diabetes mellitus and closely related to glycosylation index.

ABSTRACT:

Background

Circular RNA (circRNA) is involved in the pathological processes of various diseases. CircRNA is more stable than linear RNAs and is expressed in high levels in tissues, making it a better biomarker candidate than linear RNAs. In this study, we aimed to identify potential circRNA biomarkers of gestational diabetes mellitus (GDM).

Methods

A retrospective case-control study was conducted using data and samples from women treated at a hospital in China between July 10, 2017, and February 15, 2018. We collected serum samples from 40 healthy pregnant women (controls) and 40 women with GDM (cases) during the second trimester as well as 65 controls and 65 cases during the third trimester of pregnancy. Placenta tissues and neonatal cord blood were each from another 20 cas

SUBMITTER: Wu H 

PROVIDER: S-EPMC6368772 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature