How context can impact clinical trials: a multi-country qualitative case study comparison of diagnostic biomarker test interventions.

ABSTRACT:

Background

Context matters for the successful implementation of medical interventions, but its role remains surprisingly understudied. Against the backdrop of antimicrobial resistance, a global health priority, we investigated the introduction of a rapid diagnostic biomarker test (C-reactive protein, or CRP) to guide antibiotic prescriptions in outpatient settings and asked, "Which factors account for cross-country variations in the effectiveness of CRP biomarker test interventions?"

Methods

We conducted a cross-case comparison of CRP point-of-care test trials across Yangon (Myanmar), Chiang Rai (Thailand), and Hanoi (Vietnam). Cross-sectional qualitative data were originally collected as part of each clinical trial to broaden their evidence base and help explain their respe

SUBMITTER: Haenssgen MJ 

PROVIDER: S-EPMC6368827 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature