Identification of special key genes for alcohol-related hepatocellular carcinoma through bioinformatic analysis.

ABSTRACT:

Background

Alcohol-related hepatocellular carcinoma (HCC) was reported to be diagnosed at a later stage, but the mechanism was unknown. This study aimed to identify special key genes (SKGs) during alcohol-related HCC development and progression.

Methods

The mRNA data of 369 HCC patients and the clinical information were downloaded from the Cancer Genome Atlas project (TCGA). The 310 patients with certain HCC-related risk factors were included for analysis and divided into seven groups according to the risk factors. Survival analyses were applied for the HCC patients of different groups. The patients with hepatitis B virus or hepatitis C virus infection only were combined into the HCC-V group for further analysis. The differentially expressed genes (DEGs) between the HCCs wit

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6368834 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature