Resilience to Risk for Psychopathology: The Role of White Matter Microstructural Development in Adolescence.

ABSTRACT:

Background

One major risk factor for the development of psychopathology is a family history of psychopathology (FHP). Cross-sectional studies have shown that FHP is associated with alterations in white matter microstructure in adolescents without current psychopathology; however, whether these associations persist throughout adolescence, particularly in those who remain resilient to developing psychopathology, is unclear.

Methods

Sixty-six adolescents underwent diffusion-weighted imaging at baseline (12-16 years of age) and at one or two follow-up visits (142 total scans). Adolescents' parents completed a modified Family History Assessment Module to calculate FHP density (FHPD) based on familial alcohol use, substance use, and major depressive, generalized anxiety, substance

SUBMITTER: Jones SA 

PROVIDER: S-EPMC6368895 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature