Multisite study of the relationships between antemortem [¹¹C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology.

ABSTRACT:

Introduction

We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [¹¹C]PIB-positron emission tomography ([¹¹C]PIB-PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ-PET quantification.

Methods

Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings.

Results

CL values increased with each CERAD neuritic plaque score increment (median -3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aβ phases (increases were detected starting at phase 2) with overlap between scores/phases. PET-pathology associations were comparable across sites and unchanged when restricting the analyses

SUBMITTER: La Joie R 

PROVIDER: S-EPMC6368897 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature