Genetics of alcohol use disorder: a review.

ABSTRACT: Alcohol use disorder (AUD) represents a significant and ongoing public health concern with 12-month prevalence estimates of ∼5.6%. Quantitative genetic studies suggest a heritability of approximately 50% for AUD, and as a result, significant efforts have been made to identify specific variation within the genome related to the etiology of AUD. Given the limited number of replicable findings that have emerged from genome-wide linkage and candidate gene association studies, more recent efforts have focused on the use of genome-wide association studies (GWAS). These studies have suggested that hundreds of variants across the genome, most of small effect (R² < 0.002), contribute to the genetic etiology of AUD. The present review describes the initial, though limited, successes of GW

SUBMITTER: Deak JD 

PROVIDER: S-EPMC6368900 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature