A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer.

ABSTRACT:

Background

Differentiating between cancer patients who will experience metastasis within a short time and who will be long-term survivors without metastasis is a critical aim in healthcare. The microsatellite instability (MSI)-high tumor phenotype is such a differentiator in colorectal cancer, as patients with these tumors are unlikely to experience metastasis. Our aim in this study was to determine if germline genetic variations could further differentiate colorectal cancer patients based on the long-term risk and timing of metastasis.

Methods

The patient cohort consisted of 379 stage I-III Caucasian colorectal cancer patients with microsatellite stable or MSI-low tumors. We performed univariable analysis on 810,622 common single nucleotide polymorphisms (SNPs) under differ

SUBMITTER: Penney ME 

PROVIDER: S-EPMC6368959 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature