Identification of Fur in Pasteurella multocida and the Potential of Its Mutant as an Attenuated Live Vaccine.

ABSTRACT: Pasteurella multocida is a pathogenic microorganism that causes a variety of serious diseases in humans and animals worldwide. The global regulator gene, fur, plays an important role in pathogenesis and regulates the virulence of many bacteria. Here, we identified a fur gene in P. multocida by complementing a Salmonella Choleraesuis Δfur mutant, and characterized a fur mutant strain of P. multocida. The P. multocida Δfur mutant strain exhibited no significant differences in growth and outer membrane protein (OMP) profiles when the complemented strain was compared to the parent. Ducks were used as the model organism to determine the virulence and protection efficacy induced by Δfur mutant strain. Animal experiments

SUBMITTER: Liu Q 

PROVIDER: S-EPMC6369157 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature